MM250609: Chronic myeloid leukaemia (CML)
CML is a myeloproliferative neoplasm driven by the BCR:ABL1 fusion gene
Morphology Monday | Case MM250609
Case from an 80 something year old male who arrived with fatigue, early satiety, and notable weight loss.
MM250602: Platelet Satellitism
This week’s Morphology Monday case featured a fascinating artefact, platelet satellitism, where platelets appear to “cluster” around white blood cells, particularly neutrophils though it has also been reported around other white cells as well. Platelet satellitism is an in vitro phenomenon in which platelets surround and stick to neutrophils in a rosette-like fashion on a…
Infectious mononucleosis: when lymphocytes take centre stage
Infectious mononucleosis (IM), also known as glandular fever, is a common clinical presentation in adolescents and young adults, often caused by the Epstein-Barr virus (EBV).
Increased adhesion of blast cells in acute myeloid leukaemia
A notable feature of AML is the increased adhesiveness of these blast cells, leading them to adhere more firmly to each other and to the bone marrow microenvironment.
Plasma cell leukaemia
I had the opportunity to sit and discuss this peripheral blood film and a multiple myeloma film with Dave and Malissa from the Differential Discussions YouTube channel. You can see our discussion below: _____Image: Shared by Malissa Norfolk, Differential Discussions.
Hypergranular APML
Images from a patient with APML.
Smear cells
Smear cells aren’t confirmatory for CLL.
Microgranular APML
…showing characteristic bilobed cells and inclusions.
Bilobed neutrophils
…two neutrophils with a reduced number of nuclear lobes…