This week’s case was a 28-year-old female referred to haematology following incidental findings of thrombocytopenia on a routine full blood count. She reported occasional easy bruising but no significant bleeding history. The laboratory findings showed:

• Hb: 122 g/L
• WBC: 6.8 × 10⁹/L
• Platelets: 62 × 10⁹/L

The blood film showed large platelets and neutrophils containing pale blue, Dӧhle body like inclusions.

These features are characteristic of May–Hegglin anomaly, one of the MYH9-related disorders. This group of rare inherited conditions presents with thrombocytopenia and large platelets, sometimes accompanied by hearing loss, renal abnormalities, or cataracts.

The inclusions seen in neutrophils represent precipitated myosin heavy chain aggregates, not the reactive Dӧhle bodies seen in infections or inflammation.

You can read more about it here.