The blood film shows a genuine thrombocytopaenia, with a leukocytosis comprising predominantly of promyelocytes with Auer rods. The cells have immature nucleoli, abundant cytoplasmic granulation and approximately 25%% of the cells are bilobed. These are consistent with acute promyelocytic leukaemia.
This week’s Morphology Monday case is from a 57 year old who presented to the emergency department.
The findings are in keeping with a lymphoproliferative disorder (LPD). Given the predominance of prolymphocytes, the picture is suggestive of Prolymphocytic Leukaemia (PLL). However, this would require confirmation by flow cytometry to establish lineage and clonality.
This week’s case comes from a 62-year-old female whose sample was flagged by the analyser, but interestingly, no differential count was produced. The WBC scattergram showed an abnormal grey plot, prompting a manual film review.
This week’s case explored a blood film from a patient with known multiple myeloma, now presenting with progressive symptoms and worsening cytopenias.
This week’s case comes from a 69 year old male presenting with a increasing fatigue and back back over the past several months. He has also experiences recurrent infections recently.
This week’s case features a 14-year-old male who had just celebrated his birthday when he presented to hospital with an abnormal full blood count and some concerning symptoms.
This week’s case featured a patient with Splenic Marginal Zone Lymphoma (SMZL) a rare, indolent B-cell lymphoma typically involving the spleen, bone marrow, and peripheral blood
…a patient who presented with fatigue and splenomegaly on examination. Routine bloods showed a significant lymphocytosis, prompting further investigation.
The findings are strongly suggestive of acute leukaemia of myeloid origin, though further flow cytometry and molecular testing are essential for classification.
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