Posts

02
MM251020: P. malariae
Earlier in the week a couple of blood film images were shared as part of this week's Morphology Monday...
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Morphology Monday | Case MM251020
A middle aged traveller presented with mild, recurring fevers and general malaise several weeks and a...
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MM251013: Acute promyelocytic leukaemia (APML)
The blood film shows a genuine thrombocytopaenia, with a leukocytosis comprising predominantly of promyelocytes...
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Morphology Monday | Case MM251013
This week's Morphology Monday case is from a 57 year old who presented to the emergency department.
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MM251006: Lymphoproliferative disorder (?PLL)
The findings are in keeping with a lymphoproliferative disorder (LPD). Given the predominance of prolymphocytes,...
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Morphology Monday | Case MM251006
This week’s case comes from a 62-year-old female whose sample was flagged by the analyser, but interestingly,...
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MM250915: Renal impairment / IDA
The case underlines how multiple comorbidities can converge to produce complex red cell morphology.
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Morphology Monday | Case MM250929
This week’s case comes from a patient with a complex clinical background. The patient presented with...
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MM250915: Haemoglobin H disease
The blood film, stained with a supravital stain, revealed distinctive “golf ball” inclusions, blue precipitates...
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Morphology Monday | Case MM250915
This week’s case comes from a 35-year-old patient who presented with fatigue, mild shortness of breath...
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MM250908: P. ovale
The overall findings were consistent with Plasmodium ovale infection, one of the less common species...
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ABID – The weird and the wonderful webinar [3/3]
Following on from the foundations laid in Session 1: Tools of the Trade, and applications of those key...
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Morphology Monday | Case MM250908
This week’s case comes from a 29-year-old male who returned from a recent trip abroad. He presented to...
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MM250901: Hereditary Pyropoikilocytosis (HPP)
The blood film demonstrated striking red cell fragmentation with marked anisopoikilocytosis, microspherocytes,...
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Morphology Monday | Case MM250901
This week's Morphology Monday comes from a 6 year old child who has been experiencing chronic anaemia...
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MM250818: Haemolytic uraemic syndrome (HUS)
The blood film showed red cell fragmentation with schistocytes and occasional microspherocytes. ADAMTS13...
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Morphology Monday | Case MM250818
This week’s case comes from a 35-year-old male who presented with fatigue and pallor, easy bruising,...
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Webinar Announcement: Antibody Identification – Session 3/3
In this final session of the ABID webinar series, we’ll explore some of the more unusual and challenging...
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MM250804: Multiple myeloma
This week’s case explored a blood film from a patient with known multiple myeloma, now presenting with...
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ABID – Putting it into practice webinar [2/3]
Following on from the foundations laid in Session 1: Tools of the Trade, this session focused on applying...
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Morphology Monday | Case MM250804
This week's case comes from a 69 year old male presenting with a increasing fatigue and back back over...
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MM250728: Sickle cell disease
This week’s Morphology Monday case features a patient with known Sickle Cell Disease (SCD)
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Webinar Announcement: Antibody Identification – Session 2/3
Registration is now open for Session 2 of the Antibody Identification (ABID) Webinar Series: Putting...
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Morphology Monday | Case MM250728
This week’s Morphology Monday case comes from a 26-year-old individual with a known history of anaemia...
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04-5
MM250721: Acute lymphoblastic leukaemia (ALL)
The findings are highly suggestive of an acute leukaemia, and given the age of the patient it raises...
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04-5
Morphology Monday | Case MM250721
This week’s case features a 14-year-old male who had just celebrated his birthday when he presented to...
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MM250714: Thalassaemia
These findings raised the possibility of a haemoglobinopathy. Given the red cell morphology and raised...
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ABID - Tools of the trade webinar [1/3]
We’re thrilled to have kicked off our three-part webinar series on Antibody Identification (ABID). In...
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Morphology Monday | Case MM250714
This week’s Morphology Monday features a 60-year-old female with a history of chronic anaemia and persistent...
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MM250707: Splenic marginal zone lymphoma (SMZL)
This week’s case featured a patient with Splenic Marginal Zone Lymphoma (SMZL) a rare, indolent B-cell...
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Morphology Monday | Case MM250707
...a patient who presented with fatigue and splenomegaly on examination. Routine bloods showed a significant...
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MM250630: Megaloblastic Anaemia
The findings pointed toward a diagnosis of megaloblastic anaemia, in this case most likely due to vitamin...
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Morphology Monday | Case MM250630
Patient went to their GP and presented with fatigue and shortness of breath.
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MM250623: Acute Myeloid Leukaemia
The findings are strongly suggestive of acute leukaemia of myeloid origin, though further flow cytometry...
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Morphology Monday | Case MM250623
a patient who presented with a gastrointestinal (GI) bleed and was started on tranexamic acid (TXA) as...
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MM250616: May Hegglin Anomaly
This week’s case focused on an adult male with a platelet count in the 54×0⁹/L, identified during routine...
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Webinar Announcement: Antibody Identification – Session 1/3
Session 1: Tools of the Trade will provide a solid foundation in the basic techniques and principles...
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Morphology Monday | Case MM250616
Today’s case involves an adult male whose blood film was reviewed following an unexpected finding on...
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MM250609: Chronic myeloid leukaemia (CML)
CML is a myeloproliferative neoplasm driven by the BCR:ABL1 fusion gene
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Morphology Monday | Case MM250609
Case from an 80 something year old male who arrived with fatigue, early satiety, and notable weight...
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MM250602: Platelet Satellitism
Blood film showing platelets clustering around neutrophils. This week’s Morphology Monday case...
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Morphology Monday | Case MM250602
While assessing the film, an interesting phenomenon was noted, one that can influence how we interpret...
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Is morphology dead? Why blood films still matter in the age of automation
I explore where automation falls short and why human interpretation remains essential in spotting artefacts,...
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Infectious mononucleosis: when lymphocytes take centre stage
Infectious mononucleosis (IM), also known as glandular fever, is a common clinical presentation in adolescents...
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Morphology Monday: Six diagnostic challenges from the blood film
Special Morphology Monday feature published in The Biomedical Scientist
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Not what it seems - a challenging case of malaria
While band forms are classically linked to P. malariae, morphological overlap can occur, and a confident...
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Red Cells: Howell-Jolly bodies
Howell-Jolly bodies are small, round inclusions
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The unseen enemy: Why today matters in the fight against malaria
Malaria disproportionately affects children under five and pregnant women, especially in sub-Saharan...
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Haemoglobinopathies - The small details that make a big difference Webinar
Only Cells hosted another successful Webinar titled "Haemoglobinopathies - the small details that make...
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Cryoglobulins: A cold case in the blood
Cryoglobulins are abnormal antibodies (immunoglobulins) that precipitate or become insoluble at low...
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Leukaemic dawn (short poem)
dawn of unknown paths
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Healthcare Scientists: Advocates for excellence
What some might perceive as "difficult" or "stubborn" in healthcare scientists is, in reality, unwavering...
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Sickled crescents (short poem)
Red cells twist in crescent shape...
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Wavy wonders: Borrelia's appearance under the microscope
Borrelia's morphology is distinct; they appear as thin, helical (spiral-shaped) organisms
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Increased adhesion of blast cells in acute myeloid leukaemia
A notable feature of AML is the increased adhesiveness of these blast cells, leading them to adhere more...
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Stained with Love
In labs where life's frail secrets hide, And answers wait, deep inside,
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Winners and Losers
Who's in the right? Who's in the wrong? Who cares? We should focus on our own processes and not palm...
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TTP Diagnostics Webinar
Only Cells hosted an online webinar titled "TTP Diagnostics - Preventing a Fragmented Approach."
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Red cells: Drepanocytes
Drepanocytes or as they are commonly known, sickle cells...
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Candour
In the heat of the situation people say all sorts, but nothing prepared me for that nonchalant yet cowardly...
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O RhD Negative packed red blood cell unit
10 minutes
"Hi, it's OIR. Could I start a code red please? We have a patient on the ward who's crashed and have...
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Peripheral blood film image showing acanthocytes
Red cells: Acanthocytes
Acanthocytes are red blood cells with irregular, spiky protrusions (spicules) on their surface.
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A blood film image from a patient with a PR bleed showing hypochromic cells
Red cells: Hypochromia
Refers to pale red cells
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Peripheral blood film showing blister cells in a patient with G6PD deficiency
Red cells: Blister (hemighost) cells
Blister cells are red blood cells that have a blister or bubble like appearance on their surface.
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A blood film image from a patient with Beta thalasseamia, showing dimorphic red cells
Red Cells: Dimorphism
The presence of two distinct population of red cells.
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Basophilic stippling on a peripheral blood film from a patient with aplastic anaemia
Red cells: Basophilic stippling
Basophilic stippling refers to the presence of evenly distributed inclusions within the erythrocytes...
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Dacrocytes (tear drop cells) on a blood film from a patient with myelofibrosis
Red Cells: Dacrocytes
Peripheral blood film from a patient with myelofibrosis, showing dacrocytes (teardrop cells). Dacrocytes...
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Peripheral blood film showing spherocytes in a patient with HS
Red cells: Spherocytes
Spherocytes, unlike normal red cells are spherical in shape.
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Peripheral blood film showing elliptocytes in a patient with a hereditary elliptocytosis
Red cells: Elliptocytes
Elliptocytes are elongated red cells.
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Plasma cell leukaemia
Plasma cell in a patient with plasma cell leukaemia. I had the opportunity to sit and discuss this peripheral...
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Hypergranular APML
Images from a patient with APML.
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Red cells: Target cells
Target cells have a characteristic target or bullseye appearance.
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P. falciparum
Images showing a Plasmodium Falciparum infection
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Smear cells
Smear cells aren't confirmatory for CLL.
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May–Hegglin anomaly
Characterised by large platelets and grey spindle like inclusions within neutrophils.
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Hypogranular APML
Microgranular APML
...showing characteristic bilobed cells and inclusions.
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Haemolytic anaemia
Red cells: Polychromasia
Red cells with varying colours.
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Anisopoikilocytosis
Red cells: Anisopoikilocytosis
Cells of different sizes and shapes.
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Bilobed neutrophils
Bilobed neutrophils
...two neutrophils with a reduced number of nuclear lobes...
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Fibrin strands
Fibrin strands
Fibrin strands on a peripheral blood film.
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